Survey Responses

At a Glance

Note

  • Survey Completion: As of 2025-11-19, 8 experts have filled the survey.
  • Below are summarized all indicators grouped by categories.
  • Variables considered critically or very important by all experts are highlighted in pink.
  • Variables considered critically important by all experts are highlighted in red.



The survey included 115 indicators grouped into 4 groups and 11 sub-categories.

Of these,

  • 0 indicators were considered critically important for all experts.

  • 8 indicators were considered critically or very important for all experts.

Indicator
Case Identification:
Date of arrival/admission at facility
Suspected or confirmed infection
Admitted to hospital
Patient's city of residence
Sex
Age
Race
Height
Weight
Current occupation or work environment
Is the patient currently pregnant or was pregnant in the last 6 weeks?
International travel prior to symptom onset
list country(ies) visited:
Indicator
Vitals:
Temperature
Respiratory rate
SpO2
Heart rate
Capillary refill ≥ 3 sec
BP (systolic)
BP (diastolic)
GCS
AVPU
Vaccinations:
Vaccinated for dengue?
Previous dengue vaccination 
Dengue doses of vaccine received
Dengue date of last vaccine
Symptoms:
Symptom onset (date of first/earliest symptom)
Any ear, nose or throat problem
Losss of taste
Chest pain
Signs of pleural effusion
Any eye problem
Neurological abormality
Confusion or agitation
Headache
Seizures
Fever
Diarrhoea
Vomiting
Any bruising or bleeding
bleeding site
Skin rash
Abdominal pain
Tender abdomen
Signs of ascites
Muscle pain or aching
Fatigue or malaise
Joint pain or aching
Lymph node abnormality
Cardiac abnormality
Any vaginal problem
Laboratory and Imagery:
Radiology results available
xray Key findings
Blood count results available
Hemoglobin
Hematocrit
WCC total
Neutrophils
Lymphocytes
Platelets
Other haematology results available
PT
APTT
INR
Creatinine
Diagnosis:
Dengue virus infection
DENV serotype
DENV PCR
Arbovirus Type
Multiple Arbovirus Diagnoses
NA
Symptoms:
Indicator
Treatments:
Anticoagulants
Type of anticoagulant
Paracetamol/acetaminophen
NSAIDs
Blood transfusion
Platelets
Fluid drainage
Therapeutic pleural tap
Therapeutic ascitic tap
Renal replacement therapy (e.g., dialysis)
ECMO (extracorporeal membrane oxygenation)
Highest level of respiratory support received
Indicator
Complications:
Ascites
Severe liver disease (new onset)
Hepatic encephalopathy (any grade)
Acute hepatitis
Bleeding disorder
Shock
Sepsis
Focal neurological signs
Seizure
Pleural effusion / Ascites
Myocarditis / Pericarditis
Encephalitis / Meningitis
Cardiac arrhythmia
Cardiac arrest
Acute Respiratory Distress Syndrome (ARDS)
Acute renal injury / Acute renal failure
Urine flow rate
Severe organ impairment
Severe bleeding
Dengue shock syndrome
Outcomes/Discharge:
Escalation to which level
Discharge facility
Date of transfer
Length of hospitalization
Date of discharge
Outcome at discharge
Self-care ability at discharge (compared to before illness)
Final Diagnosis:
Main diagnosis dengue?
If no: What was the main diagnosis?
Select Primary diagnosis if it is not Dengue
If no in the above list: What was the main diagnosis?
Type of Primary diagnosis
Final Clinical Inclusion Criteria

Demographics

Dengue Physiopathology

Clinical Care

Outcomes

Discussion

Demographics/Baseline

1 2 3 4 5 6

Important

The WHO Clinical Data Platform Team analyzed responses from 8 experts to identify variables considered as:

  • Critical and kept in final CRF. Note that the item Suspected or confirmed Infection is inherent to the inclusion criteria for this CRF.
  • Open for discussion if answered as critically important or very important by >40%
  • Discarded if answered as not at all important, a little important or important by >60%


Variables Critical:

  • Age
  • Sex
  • Date of arrival/admission at facility
  • Suspected or confirmed Infection

Variables for Discussion:

  • Is the patient currently pregnant or was pregnant in the last 6 weeks?

Variables Discarded:

  • Race
  • Weight
  • Height
  • Current occupation or work environment
  • International travel prior to symptom onset
  • list country(ies) visited
  • Patient’s city of residence

Vitals

1 2 3 4 5 6

Important

The WHO Clinical Data Platform Team analyzed responses from 8 experts to identify variables considered as:

  • Critical and kept in final CRF
  • Open for discussion if answered as critically important or very important by >40%
  • Discarded if answered as not at all important, a little important or important by >60%


Variables Critical:

  • BP (diastolic/systolic)
  • Heart rate

Variables for Discussion:

  • AVPU
  • Capillary refill ≥ 3 sec
  • GCS
  • Respiratory rate
  • SpO2
  • Temperature

Variables Discarded:

Symptoms

Important

The WHO Clinical Data Platform Team analyzed responses from 8 experts to identify variables considered as:

  • Critical and kept in final CRF
  • Open for discussion if answered as critically important or very important by >40%
  • Discarded if answered as not at all important, a little important or important by >60%


1 2 3 4 5 6


Variables Critical:

  • Any bruising or bleeding (bleeding site)
  • Symptom onset (date of first/earliest symptom)

Variables for Discussion:

  • Confusion or agitation
  • Fever
  • Seizures
  • Abdominal pain
  • Vomiting
  • Signs of ascites and pleural effusion
  • Tender abdomen

Variables Discarded:

  • Any ear, nose or throat problem
  • Any eye problem
  • Any vaginal problem
  • Cardiac abnormality
  • Chest pain
  • Diarrhoea
  • Fatigue or malaise
  • Headache
  • Joint pain or aching
  • Losss of taste
  • Lymph node abnormality
  • Muscle pain or aching
  • Neurological abormality
  • Skin rash

Comorbidities

Note

  • Note: Comorbidity questions were not included in the first survey iteration. Based on the need to better characterize risk factors for dengue severity, these items have been added for future data collection.


1 2 3 4 5 6


Variables Critical:

Variables for Discussion:

  • Diabetes (type 1 or type 2)
  • Chronic heart disease (e.g., heart failure, coronary artery disease)
  • Chronic kidney disease
  • Chronic liver disease
  • Immunosuppressive condition or Immunosuppressive medication
  • Cancer diagnosis
  • Bleeding disorder or take anticoagulant/antiplatelet medication

Variables Discarded:

Laboratory and Imagery

Important

The WHO Clinical Data Platform Team analyzed responses from 8 experts to identify variables considered as:

  • Critical and kept in final CRF
  • Open for discussion if answered as critically important or very important by >40%
  • Discarded if answered as not at all important, a little important or important by >60%


1 2 3 4 5 6


Variables Critical:

  • Platelets
  • Hematocrit

Variables for Discussion:

  • Hemoglobin
  • Creatinine
  • Blood count results available

Variables Discarded:

  • APTT
  • INR
  • Lymphocytes
  • Neutrophils
  • Other haematology results available
  • PT
  • Radiology results available
  • WCC total
  • xray Key findings

Vaccinations

Important

Vaccination included 4 items. The main item Vaccinated for dengue? is considered critical and all other items are derivative from the former one:

  • Dengue date of last vaccine
  • Dengue doses of vaccine received
  • Previous dengue vaccination


1 2 3 4 5 6


Variables Critical:

  • Vaccinated for dengue

Variables for Discussion:

Variables Discarded:

Diagnosis

Important

The WHO Clinical Data Platform Team analyzed responses from 8 experts to identify variables considered as:

  • Critical and kept in final CRF
  • Open for discussion if answered as critically important or very important by >40%
  • Discarded if answered as not at all important, a little important or important by >60%


1 2 3 4 5 6


Variables Critical:

  • Dengue virus infection

Variables for Discussion:

  • DENV PCR

Variables Discarded:

  • Arbovirus Type
  • DENV serotype
  • Multiple Arbovirus Diagnoses

Treatments

Important

  • Note for experts: the item Anticoagulants (and type) has been moved to the comorbidities/pre-existing conditions section


1 2 3 4 5 6


Variables Critical:

Variables for Discussion:

  • Blood transfusion
  • Fluid drainage (Therapeutic ascitic/pleural tap included)
  • Highest level of respiratory support received
  • Platelets
  • Renal replacement therapy (e.g., dialysis)
  • NSAIDs

Variables Discarded:

  • Paracetamol/acetaminophen
  • ECMO (extracorporeal membrane oxygenation)

Complications

Note

The following variables can be merged/unified:

  • Severe bleeding and Bleeding disorder


1 2 3 4 5 6


Variables Critical:

  • Dengue shock syndrome

Variables for Discussion:

  • Acute Respiratory Distress Syndrome (ARDS)
  • Acute hepatitis
  • Acute renal injury / Acute renal failure
  • Ascites
  • Bleeding disorder
  • Cardiac arrest
  • Cardiac arrhythmia
  • Encephalitis / Meningitis
  • Focal neurological signs
  • Hepatic encephalopathy (any grade)
  • Myocarditis / Pericarditis
  • Pleural effusion / Ascites
  • Seizure
  • Sepsis
  • Severe bleeding
  • Severe liver disease (new onset)
  • Severe organ impairment
  • Shock
  • Urine flow rate

Variables Discarded:

Outcome

Note

  • The variables Date of discharge and Date of transfer can be merged as outcome included Transferred to another facility
  • The variable Discharge facility is a subquestion if Outcome at discharge==Transferred to another facility
  • The variable Length of hospitalization is deduced from Date of admission and date of discharge/transfer


1 2 3 4 5 6


Variables Critical:

  • Outcome at discharge
  • Date of discharge/transfer

Variables for Discussion:

  • Escalation to which level
  • Self-care ability at discharge (compared to before illness)

Variables Discarded:

  • Length of hospitalization
  • Discharge facility (sub-question)

Final Diagnosis

Note

  • The variablea If no in the above list: What was the main diagnosis? and If no: What was the main diagnosis? are linked to the critical indicator Main diagnosis dengue?.


1 2 3 4 5 6


Variables Critical:

  • Main diagnosis dengue?
  • Select Primary diagnosis if it is not Dengue
  • If no: What was the main diagnosis?

Variables for Discussion:

  • Final Clinical Inclusion Criteria
  • Type of Primary diagnosis

Variables Discarded:

Thank you